Saini, Vineet and McClure, J. T. and Scholl, Daniel T. and DeVries, Trevor J. and Barkema, Herman W. (Canada)
Journal of Dairy Science (2013)
Data for this study originated from the National Cohort of Dairy Farms of the Canadian Bovine Mastitis Research Network (CBMRN), which consisted of 91 commercial dairy farms located in 4 regions across Canada. Dairy herds were selected to replicate the regional proportion of freestall systems. AMU data were collected from February 2007 to December 2008. Forty-liter receptacles were placed on participating farms for collecting data for AMU. Producers, farm workers, and other farm personnel were instructed to deposit the empty containers of all drugs used by them or the veterinarian for treatment in calves, heifers, and adult cows (dry cows and lactating cows) into these receptacles. Antimicrobial use data were quantified in units of animal defined-daily doses (ADD). Minimum inhibitory concentration values were determined for 394 E. coli isolates that came from 394 quarters of 353 cows on 76 dairy farms.
3 different sets of milk samples were collected. The first set included milk samples from clinical mastitis cases. These samples were collected before and after antimicrobial treatment. The second set included milk samples from nonclinical lactating cows; a subsample of 15 fresh and lactating cows was randomly selected per farm using a computer-driven method of random sampling without replacement. The third set of milk samples were collected from another selected group of 15 cows that were expected to remain in the herd until at least 2 wk after calving. Because multiple isolates could come from a single cow, it was decided to randomly include only 1 isolate per quarter. The isolates comprised IMI and subclinical and clinical mastitis cases.
AST Method: Broth Microdilution
Reference explicitly reports AST breakpoints: False
Reference reports using a MIC table: False
Is Excluded: False
| Country | Sub-Region | Sub-Region Detail |
|---|---|---|
| Canada | Other (Other) | Alberta, Ontario, Québec, and Maritime Provinces |
| Canada | None | None |
| Canada | None | None |
| ID | Note | Resolution |
|---|
| Title | Host | Host | Production Stage | Description | ROs |
|---|---|---|---|---|---|
| Barn type | Cattle | Dairy Cows | Farm | N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 8 |
| Penicillin combination use | Cattle | Dairy Cows | Farm | Penicillin combination use for lactating cow therapy. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 1 |
| Cloxacillin use | Cattle | Dairy Cows | Farm | Cloxacillin use for dry cow therapy. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 2 |
| Penicillin-novobiocin use | Cattle | Dairy Cows | Farm | Penicillin-novobiocin use for dry cow therapy. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 2 |
| Penicillin combination use | Cattle | Dairy Cows | Farm | Combination penicillin use for lactating cow therapy. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 2 |
| Sulfamethoxazole and trimethoprim use | Cattle | Dairy Cows | Farm | Systemic sulfamethoxazole and trimethoprim use. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 2 |
| Penicillin use | Cattle | Dairy Cows | Farm | Systemic penicillin use. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 4 |
| Ceftiofur use | Cattle | Dairy Cows | Farm | Ceftiofur use for lactating cow therapy. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 3 |
| Cephapirin use | Cattle | Dairy Cows | Farm | Cephapirin use for dry cow therapy. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 2 |
| Florfenicol use | Cattle | Dairy Cows | Farm | Systemic florfenicol use. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 1 |
| Erythromycin use | Cattle | Dairy Cows | Farm | Systemic erythromycin use. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 2 |
| Tetracycline use | Cattle | Dairy Cows | Farm | Systemic tetracycline use. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 4 |
| Pirlimycin use | Cattle | Dairy Cows | Farm | Pirlimycin use for lactating cow therapy. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 1 |
| Ceftiofur use | Cattle | Dairy Cows | Farm | Systemic ceftiofur use. N = 394 isolates from bovine IMI and (sub)clinical mastitis cases on 76 dairy farms | 1 |