Reference | Dorr2009 (10160)

56 pigs that had not been exposed to antimi-crobials since birth, originating from the North Carolina State University institu-tional farm unit, were chosen for this study at approximately 3 weeks of age. Pigs challenged with Salmonella Typhimurium strain DT103 or strain DT193 (~64 days of age). The DT193 challenge group received an average dose of 8.14 × 10^8 bacteria and the DT104 group received an average dose of 2.55 × 10^8 bacteria. Nursery-aged pigs (n = 56) were randomly assigned to their respective treatment groups using a random number generator. Pigs were allocated into eight treatment groups: DT104 challenge with four antimi-crobial interventions (Control, F = Flavophospholipol, PCt = Penicillin, chlortetracycline, and PCtF = Penicillin, chlortetracycline, flavophospholipol) and DT193 challenge with the same four antimicrobial interventions. Each pig was challenged with one of the Salmonella phage types on Day -8 of the study. Fecal samples were collected from each pig three times (Days -7, -4, and -2) before antimicrobialintervention began on Day 0, then once a week in the post-intervention period until the animals were humanely euthanized approximately 15 to 17 weeks later. Antimicrobials added to feed: flavophospholipol (Flavomycin; Huvepharma Inc, Peachtree City, Georgia) at 4.85 g per tonne (Group F); penicillin and chlortetracycline, both at 11 g per tonne (Group PCt); and penicil-lin and chlortetracycline, both at 11 g per tonne, plus flavophospholipol at 4.85 g per tonne (Group PCtF).

Fecal samples were collected from each pig three times (Days -7, -4, and -2) before antimicrobialintervention began on Day 0, then once a week in the post-intervention period until the animals were humanely euthanized approximately 15 to 17 weeks later.

AST Method: None

Reference explicitly reports AST breakpoints: False

Reference reports using a MIC table: False