Reference | Dealy1976 (10154)

Influence of bambermycins on Salmonella infection and antibiotic resistance in swine.


Dealy, Jean; Moeller, M. W. (United States of America)

Journal of Animal Science (1976)

Reference


Thirty Yorkshire pigs, 4 to 5 weeks of age, obtained from Willow Glen Farm, Strasburg, Pa. were used in this study. These animals were newly weaned and had not received antibacteri- als before the start of this trial. The nonmedicated pork grower was a mix- ture containing 727.3 kg ground corn (N.R.C. 4-02-935) and 181.8 kg commercial protein supplement (Allied Mills). The medicated test feed was the same pork grower supplemented with 4.4 mg bambermycins per kilogram. Salmonella typhimurium (S. typhimurium swine strain DVR-70), kindly supplied by the Division of Veterinary Medical Research, Food and Drug Administration, Beltsville, Md., was used as the infecting organism. This organism belongs in serogroup B. The pigs were divided randomly by weight, sex and litter number into four treatment groups. Twenty pigs were used as the experi- mental animals with 10 assigned to Treatment Group A and 10 to Treatment Group B. Ten were used as environmental controls, five as- signed to Control C and five to Control D. Group A and B were inoculated with Salmonella while Group C and D were not.

Fecal samples were taken from all pigs on days 2, 4, 7, 10, 12, 14, 21, 28, 35, 42 and 49 postinfection.

AST Method: None

Reference explicitly reports AST breakpoints: True

Reference reports using a MIC table: True

Is Excluded: False

Country Sub-Region Sub-Region Detail
United States of America Pennsylvania (State) Strasburg
ID Note Resolution

Factors


Title Host Host Production Stage Description ROs
Bambermycin use Swine Weaners Farm Both groups inoculated with an MDR strain of S. Typhimurium (2.5 x 10^11 CFU), 4.4 mg/kg bambermycins added to feed for one group (starting 5d before inoculation). Measurements for days 2-21 post-inoculation (avg of 7 sampling time points) 8