Reference | Williams2018 (10133)

Effects of chlortetracycline alone or in combination with direct fed microbials on nursery pig growth performance and antimicrobial resistance of fecal Escherichia coli.


Williams, Hayden E.; Tokach, Mike D.; Dritz, Steve S.; Woodworth, Jason C.; DeRouchey, Joel M.; Nagaraja, Tiruvoor G.; Goodband, Robert D.; Pluske, John R.; Chitakasempornkul, Kessinee; Bello, Nora M.; Amachawadi, Raghavendra G. (United States of America)

Journal of Animal Science (2018)

Reference


A total of 300 nursery pigs (DNA 200 A- 400, Columbus, NE; initially 5.9 +/- 0.05 kg BW) were used in a 42-d study with five pigs per pen and 10 pens per treatment. Pigs were weaned at approximately 21 d of age and allotted to pens based on initial BW. Pigs were fed a common starter diet that did not contain in-feed antimicrobials for 4 d, after which pens were blocked by initial BW and allotted to one of six dietary treatments in a completely ran-domized block design. he six dietary treatments were arranged in a 2 A- 3 factorial consisting of combinations of CTC (chlortetracycline) (0 vs. 400 mg/kg from days 0 to 42), DFM 1 (Direct fed microbials) (0 vs. 0.05% Bioplus 2B) or DFM 2 (0 vs. 0.05% Poultry Star) added at manufacturer's recommendations. Experimental diets were fed throughout two study phases (phase 1: days 0 to 14 and phase 2: days 14 to 42) in meal form. On days 14 and 28, CTC was removed from the diet to comply with FDA regulations; when appropriate to the experimental diets, CTC was resumed on days 15 and 29.

On days 0, 21, and 42, fecal samples were col-lected by gentle rectal massage from three randomly selected pigs per pen and placed into individual plastic bags (Whirl-Pak, Nasco, Ft. Atkinson, WI), for a total of 30 samples per treatment for each sampling day.

AST Method: None

Reference explicitly reports AST breakpoints: False

Reference reports using a MIC table: False

Is Excluded: False

Country Sub-Region Sub-Region Detail
United States of America Kansas (State) Manhattan
ID Note Resolution

Factors


Title Host Host Production Stage Description ROs
Chlortetracycline + Prebiotic + Probiotic use Swine Weaners Farm 400 mg/kg chlortetracycline + direct fed microbial (0.05% Poultry Star) use for 42 days, chlortetracycline removed at days 14 & 28, and resumed days 15 & 29, respectively 12
Chlortetracycline + Probiotic Use Swine Weaners Farm 400 mg/kg chlortetracycline + direct fed microbial (0.05% Bioplus 2B) use for 42 days, chlortetracycline removed at days 14 & 28, and resumed days 15 & 29, respectively 12
Chlortetracycline use Swine Weaners Farm 400 mg/kg chlortetracycline use for 42 days, chlortetracycline removed at days 14 & 28, and resumed days 15 & 29, respectively 12
Prebiotic + Probiotic use Swine Weaners Farm Direct fed microbial (0.05% Poultry Star) use for 42 days 12
Probiotic use Swine Weaners Farm Direct fed microbial (0.05% Bioplus 2B) use for 42 days 12