Reference | Mathew2005 (10050)

Eight pregnant sows, specifically raised without therapeutic or nontherapeutic antibiotics since birth, were divided into two groups, with four sows receiving oxytetracycline at 100g/ton of feed for the 14 days prior to the anticipated farrowing date, and four sows receiving no antibiotics. Fecal samples were obtained via Dacron swabs from each sow prior to antibiotic exposure and at 1-week intervals until the pigs were weaned. Fecal samples were also obtained from pigs whenever sow samples were obtined postfarrowing, and throughout the grow-finish period until pigs reached market weight. Pigs reminaed on sows for 21 days, after which they were weaned and moved to nusery pens, with treatment groups being housed in separate, biosecure isolation rooms. Sows and pigs were managed to simulate modern commercial swine husbandry practices. Pigs were grouped according to litter and sow treatment and approximately one half of the pigs from each litter were randomly assigned to either exclusion of antibioticsa or a nontherapeutic antibiotic treatment regimen consisting of apramycin and moved accordingly to separate rooms. On day 2 post-weaning, all pigs were challenged via intranasal inoculation with nalidixic acid resistant Salmonella enterica Typhimurium.

Rectal swabs wqere obtained from pigs n day 2 following weaning (just prior to Salmonella challenge) and on days 7 (just prior to assignment to antibiotic treatments), 14, 30, 60, 114 (prior to transport of pigs), and 115 (following transport of pigs) postweaning.

AST Method: Unclear

Reference explicitly reports AST breakpoints: True

Reference reports using a MIC table: False